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RhodimetÂ®AT88* offers a way to acidify feed when supplementing methionine
When balancing feed with sulphur containing amino acids, feed producers have the choice between DL-Methionine (RhodimetÂ®NP99) and Methionine Hydroxy-analogue (RhodimetÂ®AT88). The HMTBA molecule of RhodimetÂ®AT88 has similar acidifying benefits as organic acids molecules and participates on controlling the growth of feed moulds and improving intestinal micro flora and nutrient digestibility.
In RhodimetÂ®AT88, the NH2 group of methionine found in DL-methionine is replaced by an OH-group, which gives it similar properties to organic acids. The pKa of RhodimetÂ®AT88 is lower than the pKa of most of feed acidifiers such as propionic, sorbic or acetic acid and equivalent to pKa of formic and lactic acid. The acidifying value of RhodimetÂ®AT88 is largely proven by experimental results reported in scientific publications and communications.
A well-known effect of organic acids is the enhanced gastric acidification, especially for post-weaning piglets. In vitro trials carried out on a monogastric gut model (TIM) in CERN laboratory of Adisseo prove that RhodimetÂ®AT88 decreases the need for HCl gastric secretion to achieve a target pH of 2. This is due to the capacity of RhodimetÂ®AT88, as an organic acid, to reduce the buffer effect of the diet (see explanations on ABC-4 value). Moreover a low buffer effect in feed may enhance the antimicrobial effect of organic acids as only the non-dissociated form (when pH is below pKa) is active against bacteria.
RhodimetÂ®AT88 has also a positive effect on gut micro flora. It clearly reduces the total micro flora growth. Considering total gas production in the gut, RhodimetÂ®AT88 has similar effect to formic or fumaric acids. Associated with organic acids (butyric, formic or fumaric acids), the inhibitory effect on bacteria growth is better than only organic acids. This effect is particularly significant against Campylobacter jejuni, as shown through in vitro cultures, while beneficial flora -lactobacillus and bifidobacterium- is not altered.
In vivo trials also prove the efficiency of RhodimetÂ®AT88 on Campylobacter in the gut on broilers. Several trials in the world show its specific and strong effect on Salmonella (Salmonella pullorum, Salmonella typhimurium, Salmonella enteritidis) and Clostridium perfringens. The efficacy is similar to that of potassium diformate or formic acid, and better than lactic acid.
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Article made possible through the contribution of Dr. Yves Mercier and Adisseo