Orego-Stim and Post-weaning Diarrhoea Syndrome
Post-weaning diarrhoea syndrome (PWDS) of piglets is caused mainly by enterotoxigenic Escherichia coli (ETEC) strains.
PWDS is an entity of the pig industry induced by stress factors occurring at early weaning and further complicated by opportunistic secondary pathogens. Some examples of these stressors are separation from the sow, mixing with other pigs, lack of lactogenic immunity (colostrum) and changes to their environment and diet.
In earlier days, PWDS was mainly regarded as a disease with Escherichia coli as the monocausal agent. Nowadays, PWDS is regarded as a multi-factorial problem, where management, feed composition, hygiene and other factors play an important role in expression of the disease.
An important aspect of gut resistance towards PWDS is a diverse and stable microbiota, by which competitive exclusion is generated, counteracting against growth and attachment of pathogenic bacteria.
Orego-Stim is a phytogenic feed additive containing natural oregano essential oil, extracted from a specific chemotype of Origanum vulgare ssp. hirtum. Meriden Animal Health exclusively uses the availability of this pure oregano oil for manufacture of the product.
Orego-Stim controls and prevents PWDS via the following mechanisms:
A) Controls infection
Extensive in vitro and in vivo trials have shown that Orego-Stim assists in alleviating problems associated with the presence of E. coli and other gastrointestinal pathogens. The oregano essential oil within Orego-Stim consists predominantly of a unique ratio and concentration of the natural phenolic compounds carvacrol and thymol, which are known to be powerful antimicrobial agents.
B) Promotes a balanced microbiota
A normal and healthy intestine usually consists of more than 99 percent of beneficial or non-pathogenic microorganisms. In clinical occurrences of diarrhoea, the population of these microorganisms usually drops to about 97 percent of the intestinal population, and 3 percent are taken over by pathogens through the process of competitive exclusion.
Based upon results of in vitro tests, Orego-Stim has a higher killing affinity towards pathogenic bacteria such as E. coli compared with beneficial microbes such as Bifidobacterium and Lactobacillus. This improves the balance of gut microbiota by ensuring that pathogen numbers are kept to a check and reestablishment of beneficial bacteria within the gut takes place via competitive exclusion.
C) Increases feed intake
Phenolic compounds within Orego-Stim give it a unique and aromatic flavour. The senses of taste and smell allow animals to separate undesirable or even lethal foods from those that are nutritious. Physiologically, stimulation of smell and taste acts as a preparatory factor for starting off feed consumption, contributing to generation of the sense of appetite.
Orego-Stim contains a natural mixture of different phenols, which can be used as an appetiser in livestock feeds to enhance their palatability. Due to its appetite-enhancing effects, Orego-Stim stimulates higher feed consumption when fed to post weaning piglets. The increased feed intake results in better daily weight gain, better uniformity of body weight at weaning, and also higher survivability rates at weaning.
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Article made possible through the contribution of Meriden Animal Health.