Necrotic enteritis is one of the most common and financially devastating bacterial diseases in modern poultry production, and has been reported in most poultry producing countries worldwide.
The disease is caused by Clostridium perfringens, a gram-positive, anaerobic bacterium that can be found in soil, dust, litter, feed, faeces and at low levels in the intestines of healthy birds.
There are five types of C. perfringens (A, B, C, D and E) which produce several toxins - a, ÃŸ , Â³ , | and CPE. However, the two primary types associated with necrotic enteritis in poultry are types A and C. The a-toxin is an enzyme which is believed to be key to the occurrence of necrotic enteritis, as it causes necrosis of the tips of the intestinal lining.
Necrotic enteritis outbreaks have usually been prevented by including antibiotics in feed. However, resistance to tetracyclines or macrolide-lincosamide antibiotics have been reported in various countries worldwide. Consequently, antibiotic growth promoters have been banned from feed in the EU, heightening the need for an effective alternative.
Orego-Stim is a natural, phytogenic feed additive containing oregano essential oil, extracted from a specific chemotype of Origanum vulgare ssp. hirtum. Availability of this pure oregano oil is exclusively used by Meriden Animal Health for the manufacture of this product.
Extensive in vitro and in vivo trials have proven that Orego-Stim assists in alleviating problems associated with the presence of C. perfringens and other gastrointestinal pathogens such as E. coli, Salmonella spp. and Eimeria spp.
The oregano essential oil within Orego-Stim consists predominantly of a unique ratio and concentration of the natural phenolic compounds carvacrol and thymol, which are known to be powerful antimicrobial agents.
Orego-Stim has also been proven to contain anticoccidial properties.
Because C. perfringens is nearly ubiquitous, it is important to prevent changes in the intestinal microflora that could promote its growth.
Based upon results of antimicrobial sensitivity tests, Orego-Stim has a higher killing affinity first towards the Clostridium and Salmonella group, followed by E. coli, then the Streptococcus, Staphylococcus and Enterococcus group, and lastly other bacteria, including beneficial microbes such as Bifidobacterium and Lactobacillus. So even if Orego-Stim selectively kills what may seem like only a small percentage of pathogenic bacteria in comparison to beneficial bacteria, it actually represents a large percentage of pathogen reduction. This improves the gut microbial flora by ensuring that pathogen numbers are checked and reestablishment of beneficial bacteria within the gut takes place via competitive exclusion.
In contrast to antibiotic growth promoters and coccidiostats, there has been no evidence of development of bacterial resistance from using Orego-Stim because its inhibitory effect on bacteria is due to its phenolic mode of action, which is by direct contact.
Orego-Stim is also not absorbed through the intestines into the bloodstream; hence, there are no residues in livestock products such as meat or eggs. This means that no withdrawal period is necessary and Orego-Stim can be used right up to the slaughter period.
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Article made possible through the contribution of Meriden Animal Health.