The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs
The correction of hypovolemia with acellular fluids results in acute normovolemic anemia. Whether the choice of the infusion fluid has an impact on the maintenance of oxygen (O2) supply during acute normovolemic anemia has not been investigated so far.
The choice of the intravenous fluid has an impact on the tolerance of acute normovolemic anemia induced by acellular volume replacement. Third-generation tetrastarch preparations (e.g., HES 130/0.4) appear most advantageous regarding maintenance of tissue oxygenation during progressive anemia. The underlying mechanism includes a lower degree of extravasation and favourable effects on microcirculatory function.
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Article made possible through the contribution of Andreas Pape, Saskia Kutschker, Harry Kertscho, Peter Stein, Oliver Horn, Mischa Lossen, Bernhard Zwissler and Oliver Habler and BioMed Central.