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Salmonella enterica Typhimurium infection causes metabolic changes in chicken muscle involving AMPK, fatty acid and insulin/mTOR signaling


Ryan J Arsenault, Scott Napper and Michael H Kogut



Salmonella enteric serovar Typhimurium (Salmonella Typhimurium) infection of chickens that are more than a few days old results in asymptomatic cecal colonization with persistent shedding of bacteria. We hypothesized that while the bacterium colonizes and persists locally in the cecum it has systemic effects, including changes to metabolic pathways of skeletal muscle, influencing the physiology of the avian host. This is the first report of significant cellular metabolic changes occurring systemically in chicken due to a Salmonella infection.



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Article made possible through the contribution of Ryan J. Arsenault et. Al. and Biomed Central.

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