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Livestock Production
Wednesday, April 17, 2013 11:13:15 AM
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Analysis of copy number variations in the sheep genome using 50K SNP BeadChip array

 

Jiasen Liu, Li Zhang, Lingyang Xu, Hangxing Ren, Jian Lu, Xiaoning Zhang, Shifang Zhang, Xinlei Zhou, Caihong Wei, Fuping Zhao and Lixin Du

 

 

In recent years, genome-wide association studies have successfully uncovered single-nucleotide polymorphisms (SNPs) associated with complex traits such as diseases and quantitative phenotypes. These variations account for a small proportion of heritability. With the development of high throughput techniques, abundant submicroscopic structural variations have been found in organisms, of which the main variations are copy number variations (CNVs). Therefore, CNVs are increasingly recognized as an important and abundant source of genetic variation and phenotypic diversity. In this study, we firstly constructed a sheep CNV map based on the Ovine SNP50 array.

 

 

For more of the article, please click here.

 
Article made possible through the contribution of Jiasen Liu et. Al. and Biomed Central.

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