Analysis of copy number variations in the sheep genome using 50K SNP BeadChip array
In recent years, genome-wide association studies have successfully uncovered single-nucleotide polymorphisms (SNPs) associated with complex traits such as diseases and quantitative phenotypes. These variations account for a small proportion of heritability. With the development of high throughput techniques, abundant submicroscopic structural variations have been found in organisms, of which the main variations are copy number variations (CNVs). Therefore, CNVs are increasingly recognized as an important and abundant source of genetic variation and phenotypic diversity. In this study, we firstly constructed a sheep CNV map based on the Ovine SNP50 array.
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Article made possible through the contribution of Jiasen Liu et. Al. and Biomed Central.