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Feed Tech
Monday, April 16, 2018 7:15:32 PM
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Vitanox, thoroughly selected components (Part 2)


Kevin Vanneste, product manager, Nuscience Group

 

 

In the previous article we explained the benefits of using Vitanox as a partial replacement for vitamin E. This article will show why the product proofs to be so effective as natural antioxidant.


In vitro tests


The antioxidant capacity of natural polyphenols is typically expressed via ORAC (Oxygen Radical Absorbance Capacity) values. The test measures oxidative degradation of a fluorescent molecule after being mixed with free radical initiators. Antioxidants with high antioxidant capacity give the best protection to the fluorescent molecule from oxidative degeneration resulting in the highest fluorescence.
 

 

Based on the ORAC test, natural antioxidants that show the highest antioxidant activity might wrongly be selected for application in animal diets. Because the assay does not give any information about the biological effectiveness of plant polyphenols, antioxidant effects in vivo might be negligible or even absent.


Tests with biological significance


Nuscience performed a thorough screening of plant polyphenols in the development Vitanox, a powerful natural antioxidant active in the animal. In contrast to simple in vitro tests, selection of the best components was done using a Boyden chamber containing an epithelial cell layer. Both intracellular oxidative stress and permeability of the epithelial layer were assessed.
 

Results of the ex vivo trials clearly show the intracellular antioxidative capacity of Vitanox after oxidative stress induction by hydrogen peroxide (H2O2). Vitanox protects the intestinal cell against oxidation and preserves intestinal integrity with a similar effectiveness as vitamin E.
 


In the next article, we'll show the effectiveness of Vitanox in vivo.

 


For more of the article, please click here.


Article made possible through the contribution of Kevin Vanneste and Nuscience Group

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